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Hi James, I recently reviewed the lit on calcium supplementation and fat mass in rodents. After rooting around in the methods sections, it seemed to me that all the studies showing a fat-reducing effect used calcium plus other milk components, whereas studies that used isolated calcium showed no effect. I concluded that calcium itself probably has no effect on fat mass in rodents. Regarding vitamin D, there’s a pretty compelling body of indirect evidence suggesting it protects against fat gain, including the finding that certain vitamin D receptor polymorphisms associate with fat mass. Although the controlled trials, I agree, have… Read more »
Stephan, Thank you for your comment. I myself have been doubtful whether there is an individual effect of calcium itself, although there is some data to indicate a potential effect of calcium. This paper by Bollen & Bai showed greater fat and weight gain in growing male, but not growing female rats, and the diets only differed in calcium. But I would agree with you that the presence of other dairy components is a major confounder in most of the animal studies. Regardless, it is apparent that the effect in humans is either extremely weak or non-existent. Also, I would… Read more »
Hi James, I recently reviewed the lit on calcium supplementation and fat mass in rodents. After rooting around in the methods sections, it seemed to me that all the studies showing a fat-reducing effect used calcium plus other milk components, whereas studies that used isolated calcium showed no effect. I concluded that calcium itself probably has no effect on fat mass in rodents. Regarding vitamin D, there’s a pretty compelling body of indirect evidence suggesting it protects against fat gain, including the finding that certain vitamin D receptor polymorphisms associate with fat mass. Although the controlled trials, I agree, have… Read more »
Stephan, Thank you for your comment. I myself have been doubtful whether there is an individual effect of calcium itself, although there is some data to indicate a potential effect of calcium. This paper by Bollen & Bai showed greater fat and weight gain in growing male, but not growing female rats, and the diets only differed in calcium. But I would agree with you that the presence of other dairy components is a major confounder in most of the animal studies. Regardless, it is apparent that the effect in humans is either extremely weak or non-existent. Also, I would… Read more »
Great research review James!